MASSIMO AVOLI - Dr. Massimo Avoli uses
electrophysiological and molecular techniques to examine the excitability of
forebrain neurons in rats and mice. His work focuses on the interplay of
inhibitory and excitatory influences, especially as they relate to the
genesis of synchronicity in neuronal networks. These processes are
fundamental for understanding the mechanisms underlying the generation of
seizures in epileptic patients and for developing new anti-epileptic drugs.
In his recent research, Dr. Avoli has worked with a mouse model of Fragile X
syndrome to identify the alterations in inhibition that occur in a specific
brain structure, the subiculum. This aspect might represent a fundamental
mechanism in the pathophysiogenesis of this form of mental retardation.
Several of the studies in Dr. Avoli's laboratory originate in collaborations
with his MNI colleagues (Drs. J. Gotman, D. Ragsdale, and P. Séguéla) as well
as with those in France (Drs. R. Miles and R. Pumain), Germany (Dr. R.
Köhling), Italy (Drs. G. Biagini, M. Cataldi and M. de Curtis) and the USA
(Dr. M. Rogawski). Ongoing experiments in France continue to address the
cellular and pharmacological properties of human neocortical networks in
vitro, a type of research that Dr. Avoli developed at the MNI in the early
E-mail: Massimo Avoli
Page last updated: Nov. 30, 2010 at 9:18 AM