The Neuro Team

Dr. Massimo Avoli

Curia G, Papouin T, Séguéla P, Avoli M. Downregulation of Tonic GABAergic Inhibition in a Mouse Model of Fragile X Syndrome. Cereb Cortex. 2008 Sep 11.
[Epub ahead of print]

Biagini G, Baldelli E, Longo D, Contri MB, Guerrini U, Sironi L, Gelosa P, Zini I, Ragsdale DS, Avoli M. Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. J Neuropathol Exp Neurol. 2008 67:687-701.

de Guzman P, Inaba Y, Baldelli E, de Curtis M, Biagini G, Avoli M. Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex. J Physiol. 2008 586:1867-1883.

Cataldi M, Lariccia V, Marzaioli V, Cavaccini A, Curia G, Viggiano D, Canzoniero LM, di Renzo G, Avoli M and Annunziato L. Zn2+ slows down Ca(V)3.3 gating kinetics: implications for thalamocortical activity. J Neurophysiol. 984: 2274-2284, 2007

Sudbury J and Avoli M Epileptiform synchronization in the rat insular and perirhinal cortices in vitro. Eur J Neurosci. 26: 3571-3582, 2007

Benini R and Avoli M. Altered inhibition in lateral amygdala networksin a rat model of temporal lobe epilepsy. J Neurophysiol. 95: 2143-2154, 2006.

Gigout S, Louvel J, Kawasaki H, D’Antuono M, Armand V, Kurcewicz I, Olivier A, Laschet J, Turak B, Devaux B, Pumain R and Avoli M. Role of gap junctions in human neocortical network synchronization. Neurobiol Dis 22: 496-508, 2006

Dr. Peter McPherson

Hussain, N.K., Jenna, S., Glogauer, M., Quinn, C.C., Wasiak, S., Kay, B.K., Stossel, T.P., Lamarche-Vane, N., and McPherson, P.S. (2001) The endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. Nat. Cell Biol. 3:927-932.

Wasiak, S., Legendre-Guillemin, V., Puertollano, R., Blondeau, F., Girard, M., de Heuvel, E., Hussain, N.K., Boismenu, D., Bell, A.W., Bonifacino, J.S. and McPherson, P.S. (2002) Enthoprotin, a novel clathrin-associated protein identified through subcellular proteomics. J. Cell Biol. 158:855-862.

Blondeau, F., Ritter, B., Allaire, P.D., Wasiak, S., Girard, M., Hussain, N.K., Angers, A., Legendre-Guillemin, V., Roy, L., Boismenu, D., Kearney, R.E., Bell, A.W., Bergeron, J.J.M., and McPherson, P.S. (2004) Tandem mass spectrometry analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc. Natl. Acad. Sci., USA 101:3833-3838. (selected by the Faculty of 1000)

Allaire, P.D., Ritter, B., Thomas, S., Burman, J.L., Denisov, A.Yu., Legendre-Guillemin, V., Harper, S.Q., Davidson, B.L., Gehring, K. and McPherson, P.S. (2006) Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis J. Neurosci. 26:13,202-13,212.

Ritter, B., Denisov, A.Yu., Philie, J., Allaire, P.D., Legendre-Guillemin, V., Zybergold, P., Gehring, K. and McPherson, P.S. (2007) The NECAP PHear domain increases clathrin accessory protein binding potential. EMBO J. 26:4066-4077.

Poupon, V., Girard, M. Legendre-Guillemin, V., Thomas, S., Bourbionniere, L., Philie, J., Bright, N.A. and McPherson, P.S. (2008) Clathrin-light chains function in mannose phosphate receptor trafficking via regulation of actin assembly. Proc. Natl. Acad. Sci., USA, 105:168-173. (selected by the Faculty of 1000)

Burman, J.L., Bourbonniere, L., Philie, J., Stroh, T., Dejgaard, S.Y., Presley, J.F. and McPherson, P.S. (2008) Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. J. Biol. Chem. 283:22774-22786. (selected as a JBC paper of the week)

Katoh, Y., Ritter, B., Gaffry, T., Blondeau, F., Höning, S., and McPherson, P.S. (2009) The clavesin family: neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. J. Biol. Chem. 284: 27646-27654.

Trempe, J-F., Chen, C.X-Q., Grenier, K., Matta Camacho, E., Kozlov, G. McPherson, P.S. Gehring, K., and Fon, E.A. (2009) SH3 domains from a subset of BAR-proteins define a novel Ubl-binding domain and implicate parkin in synaptic ubiquitination Mol. Cell 36: 1034-1047. (Selected as an Editor’s choice, Science, Vol 327: 505, 2010).

Allaire, P.D., Marat, A.L., Dall’Armi, C., Di Paolo, G., McPherson, P.S.*, and Ritter, B*. (2010) The connecdenn DENN domain: A GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol. Cell. 37: 370-382. *=co-corresponding author.

Marat, A.L. and McPherson, P.S. (2010) The connecdenn family: Rab35 guanine-nucleotide exchange factors interfacing with the clathrin machinery. J. Biol. Chem. 285: 10627-10637.

Dr. Liliana Pedraza

Liliana Pedraza, Jeffrey K. Huang and David Colman Disposition of Axonal Caspr With Respect to Glial Cell Membranes: Implications for the Process of Myelination J. Neurosci. Res., 2009 Jan 23 (Epub ahead of print).

Huang JK, Phillips GR, Roth AD, Pedraza L, Shan W, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR 3rd, Colman DR. Glial membranes at the node of Ranvier prevent neurite outgrowth. Science. 2005 Dec 16;310(5755):1813-7.

Svenningsen AF, Colman DR and Pedraza L. Satellite cells of dorsal root ganglia are multipotential glial precursors. Neuron Glia Biology, 2004 1:85-93.

Svenningsen AF, Shan W-S, Colman DR and Pedraza L A rapid method for culturing embryonic neuron-glial co-cultures J. Neurosci. Res. 2003 Jun 1;72(5):565-73.

Pedraza L, Huang JK and Colman DR. Organizing principles of the axoglial apparatus. Neuron. 2001 May;30(2):335-44

Dr. David Ragsdale

Ragsdale, D.S., McPhee, J.C., Scheuer, T., and Catterall, W.A. Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science 265:1724-1728 (1994).

Li, H.-L., Galue, A., Meadows, L., and Ragsdale, D.S. A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel. Mol. Pharmacol. 55:134-141 (1999).

Magistretti, J., Ragsdale, D.S., and Alonso, A. Direct demonstration of persistent Na+ channel activity in dendritic processes of mammalian cortical neurons. J. Physiol. 521:629-636 (1999).

Meadows, L.S., Malhotra, J., Loukas, A., Thyagarajan, V., Kazen-Gillespie, K.A., Koopman, M.C., Kriegler, S., Isom, L.L., Ragsdale, D.S.* Functional and biochemical analysis of a sodium channel 1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1. J. Neurosci. 22:10699-10709 (2002).

Cossette, P., Loukas, A†., LaFrenière, R.G., Rochefort, D., Ragsdale, D.S., Dunn R., Rouleau, G.A. Functional characterization of the D188V mutation in the neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus. Epilepsy Res. 53:107-117 (2003).

Ragsdale D.S. How do mutant Nav1.1 sodium channels cause epilepsy? Brain Res. Rev. 58: 149-159 (2008).

Dr. Ed Ruthazer

Ruthazer, E.S. (2005) You’re Perfect, Now Change – Redefining the Role of Developmental Plasticity Neuron, 45(6): 825-8.

Ruthazer, E.S., Li, J.L., and Cline, H.T. (2006) Stabilization of Axon Branch Dynamics by Synaptic Maturation Journal of Neuroscience 26: 3594-603.

Latefi,N.S., Pedraza,L. Schohl, A.. Li, Z. and Ruthazer,E.S. (2009) N-cadherin prodomain cleavage regulates synapse formation in vivo, Developmental Neurobiology. 69(8): 518-529.

Schwartz N., Schohl, A. and Ruthazer, E.S. (2009) Neural activity regulates synaptic properties and dendritic structure in vivo through calcineurin/NFAT signaling, Neuron, 62, 655–669.

Tremblay, M., Fugère, V., Tsui, J., Schohl, A., Tavakoli, A., Travençolo, B.A.N., Costa,L, and Ruthazer E.S. (2009) Regulation of Radial Glial Motility by Visual Experience, J. Neuroscience 29: 14066-76.

Ruthazer, E.S. and Aizenman, C.D. (2010) Learning to See: Patterned visual activity and the development of visual function. Trends in Neuroscience,33: 183-92.

Higenell, V. and Ruthazer, E.S. (2010) Layers upon Layers: MHC Class I Acts in the Retina to Influence Thalamic Segregation Neuron 65: 439-41.

Tsui, J., Schwartz, N. and Ruthazer, E.S. (2010) A developmental sensitive period for spike timing-dependent plasticity in the retinotectal projection Frontiers in Synaptic Neuroscience, in press. Special Topic on STDP, edited by H. Markram, J. Sjöström and W. Gerstner .

Ruthazer, E.S., Bachleda, A.R., and Olavarria, J.F. The Role of Interstitial Branching in the Development of Visual Corticocortical Connections: A Time-lapse and Fixed-tissue Analysis., Journal of Comparative Neurology, in press.

Sild, M. and Ruthazer, E.S. Radial Glia: Progenitor, Pathway and Partner, The Neuroscientist, in press.

Dr. Philippe Séguéla

Bernier L.-P., Ase R.A., Chevallier S., Blais D., Zhao Q., Logothetis D.E., Séguéla P. (2008) Phosphoinositides regulate P2X4 ATP-gated channels through direct interactions. Journal of Neuroscience 28 :12938-12945.

Bernier L.-P., Ase AR, Tong X, Hamel E, Blais D, Zhao Q, Logothetis D, Séguéla P. (2008) Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate. Molecular Pharmacology 53: 496-504.

Zhao, Q., Logothetis, D.E., Seguela, P. (2007) Regulation of ATP-gated P2X receptors by phosphoinositides. Eur. J. Physiol. 455:181-185.

Reboreda A., Raouf R., Alonso A.A. and Séguéla P. (2007) Development of cholinergic modulation and graded persistent activity in Layer V of medial entorhinal cortex. Journal of Neurophysiology 97:3937-3947.

Sharif Naeini, R., Witty, M.F., Séguéla, P., Bourque CW. (2006) An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 9:93-98.

Dr. Wayne Sossin

Weatherill, D, Dyer JR and Sossin WS. (2010) Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia J. Biol. Chem. 285: 12255-12567

Wang DO, Kim S, Zhao Y, Hwang H, Mioru S, Sossin WS and Martin KC (2009). Synapse- and stimulus-specific local translation during long-term neuronal plasticity Science 324:1536-40

Abi-Farah C, Weatherill DW, Tyler, WJ and Sossin WS. (2009) PKC differentially translocates during spaced and massed training in Aplysia. J. Neurosci. 29:10281-6.

Bougie JK, Lim T, Abi Farah C, Manjunath V, Nagakura I, Ferraro GB and Sossin WS (2009) The Atypical Protein Kinase C in Aplysia can form a PKM by cleavage. J. Neurochem 109:1129-1143

Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. (2009) Translational control of long-lasting synaptic plasticity and memory Neuron 15:10-26

Sossin WS (2008) Defining memories by their distinct molecular traces. Trends Neurosci. 31:170-175.