Dr. Jack Antel’s research program focuses on using human neural and immune cells to understand how their interactions contribute to the development of neurological disease, specifically multiple sclerosis. The studies include how immune cells reach the central nervous system, how the state of activity of the endogenous glial cells contributes to persistence of the immune response, and how the immune mediators induce injury of the target cells, namely oligodendrocytes and neurons and their processes. These studies also aim to understand how the nervous system is able to repair itself from such injury.

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E-mail: Jack Antel