The Neuro Team

Dr. Jack Antel

Miron VE, Jung CG, Kim HJ, Kennedy TE, Soliven B, Antel JP. FTY720 modulates human oligodendrocyte progenitor process extension and survival. Annals of Neurology. 63(1):61-71 (2008).

Darlington PJ, Podjaski C, Horn KE Costantino S, Blain M, Saikali P, Chen Z, Baker KA, Newcombe J, Freedman M, Wiseman PW, Bar-Or A, Kennedy TE, Antel JP. Innate Immune-mediated Neuronal Injury Consequent to Loss of Astrocytes. J Neuropathology and Experimental Neurology 67: 590-599 (2008).

Kuhlmann T, Miron V, Cuo Q, Wegner C, Antel J, Bruck W Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131: 1749-1758 (2008).

Miron V, Hall JA, Kennedy TE, Soliven B, Antel JP Cyclical and Dose-Dependent Responses of Adult Human Mature Oligodendrocytes to FTY720. Am J Pathol 1143-52 (2008).

Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, Antel JP. Functional consequences of neuromyelitis optica-immunoglobulin-G: astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J. Immunology 181:5730-7 (2008).

Lambert C, Desbarats J, Arbour N, Hall JA, Olivier A, Bar-Or A, Antel JP Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia. J Immunology. 181(12):8288-97 (2008).

Dr. Amit Bar-Or

Incidence of acquired demyelination of the CNS in Canadian children. Banwell B, Kennedy J, Sadovnick D, Arnold DL, Magalhaes S, Wambera K, Connolly MB, Yager J, Mah JK, Shah N, Sebire G, Meaney B, Dilenge ME, Lortie A, Whiting S, Doja A, Levin S, MacDonald EA, Meek D, Wood E, Lowry N, Buckley D, Yim C, Awuku M, Guimond C, Cooper P, Grand'Maison F, Baird JB, Bhan V, Bar-Or A. Neurology. 2009 Jan 20;72(3):232-9

Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. Vincent T, Saikali P, Cayrol R, Roth AD, Bar-Or A, Prat A, Antel JP. J Immunol. 2008 Oct 15;181(8):5730-7.

B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators. Rieger A, Bar-Or A. Nat Rev Immunol. 2008 Jun;8(6):486-7

Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes. Banwell B, Bar-Or A, Cheung R, Kennedy J, Krupp LB, Becker DJ, Dosch HM; Wadsworth Pediatric Multiple Sclerosis Study Group. Ann Neurol. 2008 Jan;63(1):98-111

Bar-Or, A., Vollmer, T., Antel, J., Arnold, D. L., Bodner, C.A., Campagnolo, D., Gianettoni, J., Jalili, F., Kachuck, N., Lapierre, Y., Niino, M., Oger, J., Price, M., Rhodes, S., Robinson, W.H., Shi, F.-D., Utz, P.J., Valone, F., Weiner, L., Steinman, L., Garren, H.. Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase I/II trial In Press, Arch Neurol 2007.

Duddy, M., Niino, M., Adatia, F., Hebert, S., Freedman, M., Atkins, H., Kim, H.J., Bar-Or, A. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol, 15;178(10):6092-9, 2007.

Niino, M., Bodner, C., Simard, M.L., Alatab, S., Gano, D., Kim, H.J., Trigueiro, M., Racicot, D., Guérette, C., Antel, J.P., Fournier, A., Grand'Maison, F., Bar-Or, A. Natalizumab effects on Immune Responses in multiple sclerosis. Ann Neurol, 59(5):748-54; 2006.

Dr. Josephine Nalbantoglu

Dudley RW, Lu Y, Gilbert R, Matecki S, Nalbantoglu J, Petrof BJ, Karpati G.
Abstract Sustained improvement of muscle function one year after full-length dystrophin gene transfer into mdx mice by a gutted helper-dependent adenoviral vector. Hum Gene Ther. 2004 Feb;15(2):145-56. PMID: 14975187 [PubMed - in process]

Batulan Z, Shinder GA, Minotti S, He BP, Doroudchi MM, Nalbantoglu J, Strong MJ, Durham HD.
Abstract High threshold for induction of the stress response in motor neurons is associated with failure to activate HSF1. J Neurosci. 2003 Jul 2;23(13):5789-98. PMID: 12843283 [PubMed - indexed for MEDLINE]

Gilbert R, Dudley RW, Liu AB, Petrof BJ, Nalbantoglu J, Karpati G.
Abstract Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin. Hum Mol Genet. 2003 Jun 1;12(11):1287-99. PMID: 12761044 [PubMed - indexed for MEDLINE]

Wosik K, Antel J, Kuhlmann T, Bruck W, Massie B, Nalbantoglu J.
Abstract Oligodendrocyte injury in multiple sclerosis: a role for p53. J Neurochem. 2003 May;85(3):635-44. PMID: 12694389 [PubMed - indexed for MEDLINE]

Nalbantoglu J, Larochelle N, Wolf E, Karpati G, Lochmuller H, Holland PC.
Free Full Text Muscle-specific overexpression of the adenovirus primary receptor CAR overcomes low efficiency of gene transfer to mature skeletal muscle. J Virol. 2001 May;75(9):4276-82. PMID: 11287577 [PubMed - indexed for MEDLINE]

Wosik K, Becher B, Ezman A, Nalbantoglu J, Antel JP.
Abstract Caspase 8 expression and signaling in Fas injury-resistant human fetal astrocytes. Glia. 2001 Mar 1;33(3):217-24. PMID: 11241739 [PubMed - indexed for MEDLINE]

Ladiwala U, Li H, Antel JP, Nalbantoglu J. Abstract p53 induction by tumor necrosis factor-alpha and involvement of p53 in cell death of human oligodendrocytes. J Neurochem. 1999 Aug;73(2):605-11. PMID: 10428056 [PubMed - indexed for MEDLINE]

Ghribi O, Lapierre L, Girard M, Ohayon M, Nalbantoglu J, Massicotte G.
Abstract Hypoxia-induced loss of synaptic transmission is exacerbated in hippocampal slices of transgenic mice expressing C-terminal fragments of Alzheimer amyloid precursor protein. Hippocampus. 1999;9(3):201-5. PMID: 10401636 [PubMed - indexed for MEDLINE]

Galipeau J, Li H, Paquin A, Sicilia F, Karpati G, Nalbantoglu J.
Free Full Text Vesicular stomatitis virus G pseudotyped retrovector mediates effective in vivo suicide gene delivery in experimental brain cancer. Cancer Res. 1999 May 15;59(10):2384-94. PMID: 10344748 [PubMed - indexed for MEDLINE]

Nalbantoglu J, Pari G, Karpati G, Holland PC.
Abstract Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells. Hum Gene Ther. 1999 Apr 10;10(6):1009-19. PMID: 10223734 [PubMed - indexed for MEDLINE]

Li H, Alonso-Vanegas M, Colicos MA, Jung SS, Lochmuller H, Sadikot AF, Snipes GJ, Seth P, Karpati G, Nalbantoglu J.
Free Full Text Intracerebral adenovirus-mediated p53 tumor suppressor gene therapy for experimental human glioma. Clin Cancer Res. 1999 Mar;5(3):637-42. PMID: 10100717 [PubMed - indexed for MEDLINE]

Nalbantoglu J, Tirado-Santiago G, Lahsaini A, Poirier J, Goncalves O, Verge G, Momoli F, Welner SA, Massicotte G, Julien JP, Shapiro ML.
Abstract Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 1997 May 29;387(6632):500-5. PMID: 9168112 [PubMed - indexed for MEDLINE]

Shekarabi M, Bourbonniere M, Dagenais A, Nalbantoglu J.
Abstract Transcriptional regulation of amyloid precursor protein during dibutyryl cyclic AMP-induced differentiation of NG108-15 cells. J Neurochem. 1997 Mar;68(3):970-8. PMID: 9048742 [PubMed - indexed for MEDLINE]