The Neuro Team
Dr. Tsuda's research aims to determine the function of genes relevant to major neurodegenerative disorders. His laboratory uses powerful genetic techniques developed for Drosophila, and applies the findings to mouse studies. Dr. Tsuda believes that dissecting pathways using flies and mice is a productive approach in analyzing resultant cellular phenotypes and in uncovering the molecular pathways that underlie amyotrophic lateral sclerosis, Parkinson's Disease, Alzheimer's Disease and other devastating neurological diseases.
Dr. Tsuda's combined analysis of flies and mice has proved valuable in understanding the pathology of neurodegeneration. He has explored the mechanisms underlying Spinocerebellar Ataxia type 1 (SCA1) as well as ALS. In both diseases, he revealed novel neurobiological pathways and pathological defects that led to aberrant phenotypes. His findings have shed light on general neurodegenerative mechanisms, opening possible routes for developing new treatments.
In a significant development, Dr. Tsuda's laboratory has introduced a fly model that carries a mutant ALS protein. This model shows many pathological features common to sporadic and familial forms of ALS. His laboratory's Drosophila studies have successfully uncovered several novel signaling pathways that could be relevant for core ALS pathology. The laboratory has established, moreover, a mouse model carrying the ALS mutation. This mouse model will be useful in preclinical trials for ALS-targeted therapies. As a result, Dr. Tsuda's laboratory is in an excellent position to expand our understanding of ALS pathogenesis and to contribute to the development of more effective therapies for ALS and other deadly neurological diseases.