Dr. Alyson Fournier's research focuses on the molecular and cellular biology of neurite outgrowth and growth cone guidance. Neurons in the central nervous system fail to spontaneously regenerate following injury. The abortive regenerative response can be attributed to a lack of positive cues to support neurite outgrowth, and to the inhibitory environment of the CNS lesion site. While there has been progress in the characterization of myelin-associated proteins and glial scar components that inhibit neurite outgrowth, the mechanism of action of inhibitory proteins remains ill defined. The aim of Dr. Fournier's research program is to develop a better understanding of the molecular components participating in neurite outgrowth and growth cone collapse. We are particularly interested in studying rho family GTPases and their downstream effectors due to their effects on the actin cytoskeleton. A fuller understanding of the mechanism of outgrowth inhibition will be used to develop strategies to promote regenerative growth.

For more information, please visit the lab website. Dr. Alyson Fournier holds a Tier II Canada Research Chair (www.chairs.gc.ca).

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E-mail: Alyson Fournier
Web Sites: Canada Research Chairs , Fournier Lab