The Neuro Team

Dr. Philip Barker

Ceni* C. Kommaddi RP, Thomas R, Vereker V, Liu X, McPherson PS, Ritter B, Barker PA. (2010) The intracellular domain of the p75 neurotrophin receptor generated by Trk activation potentiates Trk signaling. J Cell Science. In press.

Thomas RA, Favell K, Morante-Redolat J, Kent C, Wright M, Pool M, Daignault K, Fournier A, Perez- Tur J, Barker PA. (2010) LGI1 is a Nogo Receptor 1 ligand that antagonizes myelin-based growth inhibition. Journal of Neuroscience. In press.

Barker PA, (2009). A p75NTR Pivoting Paradigm Propels Perspicacity. Neuron. 62:3-5

Lebrun-Julien F, Bertrand M, De Backer O, Stellwagen D, Morales C, Di Polo A, Barker PA. ProNGF induces TNF-alpha-dependent death of retinal ganglion cells through a p75NTR Non-Cell-Autonomous Signaling Pathway. Proc Natl Acad Sci U S A. 107:3817-22.

Bertrand MJM, Doiron K, Labbé K, Barker PA*1 and Saleh M1. (2009) cIAP1 and cIAP2 are required for NOD-mediated innate immunity signaling. Immunity. 30(6): 789-801.

Barker PA, (2009). Whither BDNF. Nature Neuroscience. 12. 1-3.

Boutilier J, Ceni C, Pagdala PC, Forgie A, Neet KE, Barker PA. (2008). Proneurotrophins require endocytosis and intracellular proteolysis to induce TrkA activation. Journal of Biological Chemistry. 283:12709-16.

Bertrand, M, Miutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA. (2008). cIAP2 is a K63 ubiquitin ligase for RIP1 that can be targeted by IAP antagonists to induce death receptor apoptosis via autocrine TNF. Molecular Cell. 30(6):689-700.

Dr. Edward Fon

Durcan TM*, Fon EA. Autophagy. 2011;7 (2):75-76

Durcan TM*, Kontogiannea M*, Thorarinsdottir T*, Fallon L*, Williams AJ, Djarmati A, Fantaneanu T*, Paulson HL, Fon EA. The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Hum. Mol. Genet. 2011;20(1):141-54

Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX*, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum. Mol. Genet. 2010;19(19):3734-46 Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F. USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly. EMBO J. 2010;29(9):1499-509

Bouvier D, Tremblay ME, Riad M, Corera AT*, Gingras D, Horn KE, Fotouhi M, Girard M, Murai KK, Kennedy TE, McPherson PS, Pasquale EB, Fon EA, Doucet G. EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain. J. Neurochem. 2010; 113:153-165

Trempe JF, Chen CXQ*, Grenier K*, Camacho EM, Kozlov G, McPherson PS, Gehring K, Fon EA. SH3 Domains from a Subset of BAR-Proteins Define a Novel Ubl-Binding Domain and Implicate Parkin in Synaptic Ubiquitination. Mol. Cell 2009; 36(6):1034-47. Corera AT*, Doucet G, Fon EA. Long-Term Potentiation in Isolated Dendritic Spines. PLoS ONE. 2009; 4(6): e6021. doi:10.1371/journal.pone.0006021.

Cookson MR, Dauer W, Dawson TM, Fon EA, Guo M, Shen J. The roles of kinases in familial Parkinson’s disease. J. Neurosci. 2007; 27(44):11865-8

Kaiser P, Fon EA. Keystone Meeting on Ubiquitin and Signaling: Expanding Horizons at Big Sky. EMBO Rep. 2007; 8(9):817-22. Joch M*, Ase AR, Chen CXQ*, MacDonald PA*, Kontogiannea M*, Corera AT*, Brice A, Séguéla P, Fon EA. Parkin-Mediated Monoubiquitination of the PDZ Protein PICK1 Regulates ASIC Channel Activity. Mol. Biol. Cell. 2007; 18(8):3105-18. Zhou L, Martinez SJ, Haber M, Jones EV, Bouvier D*, Doucet G, Corera AT*, Fon EA, Zisch AH, Murai KK. EphA4 signaling regulates phospholipase Cgamma1 activation, cofilin membrane association, and dendritic spine morphology. J. Neurosci. 2007; 27(19):5127-38.

Fallon L*, Bélanger CML*, Corera AT*, Kontogiannea M*, Regan-Klapisz E, Moreau F*, Voortman J, Haber M*, Rouleau G*, Thorarinsdottir T*, Brice A, van Bergen en Henegouwen P, Fon EA. A Regulated Interaction with the UIM-protein Eps15 Implicates Parkin in EGF Receptor Trafficking and PI3K-Akt Signaling. Nat. Cell Biol. 2006; 8(8):834-42

Dr. Timothy Kennedy

Lai Wing Sun K, Correia JP, Kennedy TE (2011) Netrins: versatile extracellular cues with diverse functions. Development, 138(11):2153-69.

Xu B, Goldman JS, Rymar VV, Forget C, Lo PS, Bull SJ, Vereker E, Barker PA, Trudeau LE, Sadikot AF, Kennedy TE. (2010) Critical Roles for the Netrin Receptor DCC in Dopaminergic Neuronal Precursor Migration, Axon Guidance, and Axon Arborization. Neuroscience. 169(2):932-49.

Rajasekharan S, Baker KA, Horn KE, Jarjour AA, Antel JP, Kennedy TE (2009) Netrin-1 and DCC Regulate Oligodendrocyte Process Branching and Membrane Extension via Fyn and RhoA. Development, 136:415-426.

Bélisle JM, Correia JP, Wiseman PW, Kennedy TE, Santiago Costantino (2008) Patterning protein concentration using laser-assisted adsorption by photobleaching, LAPAP. Lab on a Chip. 8(12): 2164-2167.

Jarjour AA, Bull SJ, Almasieh M, Rajasekharan S, Baker KA, Mui J, Antel JP, Di Polo A, Kennedy TE (2008) Maintenance of Axo-Oligodendroglial Paranodal Junctions Requires DCC and Netrin-1. Journal of Neuroscience. 28: 11003-11014.

Moore SW, Correia J, Lai Wing Sun K, Pool M, Fournier AE, and Kennedy TE. (2008) Rho Inhibition Recruits DCC to the Neuronal Plasma Membrane and Enhances Axon Chemoattraction to Netrin-1, Development, 135(17):2855-64.

Baker KA, Moore SW, Jarjour AA, and Kennedy TE (2006) When a diffusible axon guidance cue stops diffusing: Roles for netrins regulating adhesion and morphogenesis. Current Opinion in Neurobiology 16(5):529-534.

Shekarabi M, Moore SW, Tritsch NX, Morris SJ, Bouchard JF, Kennedy TE (2005). DCC binding netrin-1 mediates cell-substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. Journal of Neuroscience. 25: 3132-3141.

Dr. Stefano Stifani

Buscarlet, M., Perin, A., Laing, A., Brickman, J.M., and Stifani, S. (2008) Inhibition of cortical neuron differentiation by Gro/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides. J. Biol. Chem. 283, 24881-24888.

Stifani, N., Freitas, A, Liakhovitskaia, A., Medvinsky, A., Kania, A., and Stifani, S. (2008). Suppression of interneuron programs and maintenance of selected spinal motor neuron fates by the transcription factor AML1/Runx1. Proc. Natl. Acad. Sci. USA 105, 6451-6456.

Belanger-Jasmin, S., Llamosas, E., Tang, Y., Joachim, K., Osiceanu, A.M., Jhas, S., and Stifani, S. (2007). Inhibition of cortical astrocyte differentiation by Hes6 requires amino- and carboxy-terminal motifs important for dimerization and phosphorylation. J. Neurochem. 103, 2022-2034.

Jhas, S., Ciura, S., Belanger-Jasmin, S., Dong, Z., Llamosas, E., Theriault, F.M., Joachim, K., Tang, Y., Liu, L., Liu, J., and Stifani, S. (2006). Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms. J. Neurosci. 26, 11061-11071.

Shen, Q., Wang, Y., Dimos, J.T., Fasano, C.A., Phoenix, T.N., Lemischka, I.R., Ivanova, N.B., Stifani, S., Morrisey, E.E., and Temple, A. (2006). The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nature Neurosci. 9, 743-751.

Theriault, F.M., Nuthall, H.N., Dong, Z., Lo, R., Barnabe-Heider, F., Miller, F.D., and Stifani, S. (2005). Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system. J. Neurosci. 25, 2050-2061.

Dr. Alyson Fournier

Ong Tone S., Dayanandan B, Fournier, A.E*., Mandato, C.A.*. (2010) GSK3 Regulates Mitotic Chromosomal Alignment through CRMP4. PLoS ONE 5(12): e14345. * Co-corresponding authors.

Kent, C., Shimada, T., Ferraro, G., Rodriguez, S., Yam, P., Ritter, B., McPherson, P., Charron, F., Kennedy, T., Fournier, A.E. (2010) 14-3-3 proteins regulate growth cone responses through PKA. J. Neurosci. 30(42): 14059-14067

McKerracher, L., Fehlings, M., Fournier, A., Ong Tone, S. (2010 - In Press). Targeting Rho inactivation to promote regeneration and treat spinal cord injury: Bench to bedside translational medicine.. In: Essential of Spinal Cord Injury, Thieme Medical Publishers Inc. NY, NY.

Thomas, R., Favell, K., Morante-Redolat, J.M., Kent, K., Wright, M., Poole, M., Daignault, K., Fournier, A.E., Pérez-Tur, J., Barker, P.A. (2010) LGI1 is a Novel Nogo Receptor Ligand that Blocks Myelin-based Growth Inhibition. Journal of Neuroscience: In press

Alabed, Y.Z., Pool, M., Ong Tone, S., Sutherland, C., Fournier, A.E. (2010) GSK3b regulates myelin dependent axon outgrowth inhibition through CRMP4. Journal of Neuroscience: In press

O'Connor, K.C., Lopez-Amaya, C., Gagne, D., Moore, N.H., Kennedy, J., Krupp, L., Tenembaum, S., Ness, J., Belman, A., Boiko, A., Bykova, O., Mah, J., Stoian, C., Waubant, E., Kremenchutzky, M., Ruggieri, M., Bardini, M.R., Rensel, M., Hahn, J., Weinstock-Guttman, B., Yeh, A., Farrell, K., Freedman, M., Livanainen, M., Bhan, V., Dilenge, M., Hancock, M.A., Gano, D., Fattahie, R., Kopel, L., Fournier, A.E., Hafler, D.A., Moscarello, M., Banwell, B., Bar-Or, A. (2010) Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J. Neuroimmunol., doi:10.1016/j.jneuroim.2010.02.019

Nash, M., Pribiag, H., Fournier, A.E., Jacobson, C. (2009) Central Nervous System Regeneration Inhibitors and their Intracellular Substrates. Mol. Neurobiology DOI 10.1007/s12035-009-8083-y

Pool, M., Niino, Rambaldi, I., Robson, K., Bar-Or, A., Fournier, A.E. (2009) Myelin regulates immune cell adhesion and motility. Exp. Neurol. 217(2):371-7

Moore, S.W., Correia, J.P., Lai Wing Sun, K., Pool, M., Fournier, A.E., Kennedy, T.E.. (2008) Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. Development. 135(17):2855-64

Costantino, S., Kent, C.B., Godin, A.G., Kennedy, T.E., Wiseman, P.W., Fournier, A.E. (2008). Semi-Automated Quantification of filopodial dynamics. J. Neurosci. Methods 171(1): 165-173

Pool, M., Thiemann, J., Bar-Or, A., Fournier, A.E. (2008) NeuriteTracer: A novel ImageJ plugin for automated quantification of neurite outgrowth. J. Neurosci. Methods 168(1):134-139.

Alabed, Y.Z., Pool, M., OngTone, S., Fournier, A.E. (2007) Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition. J. Neurosci. 27, 1702-1711.

Darenfed, H., Dayandana, B., Hsieh, S. H.-K., Fournier, A.E., Mandato. C.A. (2007) Molecular Characterization of the Effects of Y-27632. Cytoskeleton and Cell Motility. 64, 97-109.

Niino, M., Bodner, C., Simard, M.-L., Alatab, S., Gano, D., Kim, H., Trigueiro, M., Racicot, D., Guérette, C., Mainville, M., Antel, J.P., Fournier, A.E., Grand’Maison, F., Bar-Or, A. (2006) Natalizumab Effects on Immune Cell Responses in Multiple Sclerosis: The Expected and Less Expected. Ann. Neurol. 59:748–754.

Alabed, Y.Z., Grados-Munro, E., Ferraro, G.B., Hsieh, S.H.-K., Fournier, A.E. (2006) Neuronal responses to myelin are mediated by ROCK. J. Neurochem. 96, 1616-1625

Hsieh, S. H.-K., Ferraro, G.B., Fournier, A.E. (2006) Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through Lim kinase and Slingshot phosphatase. J. Neurosci. 26(3), 1006-1015.

Dr. Jean-François Cloutier

Prince, J. E. A., Cho, J.H., Dumontier, E., Andrews W., Cutforth, T., Tessier-Lavigne, M., Parnavelas, J., Cloutier, J.-F. (2009) Robo-2 controls the segregation of a portion of basal vomeronasal sensory neuron axons to the posterior region of the accessory olfactory bulb. J. Neurosci. 29:14211-14222.

Beaubien, F. and Cloutier, J.F. (2009) Differential expression of Slitrk family members in the mouse nervous system. Dev. Dyn. 238:3285-3296.

Cho, J.H., Prince, J.E.A., Cloutier, J.-F. (2008) Axon guidance events in the wiring of the mammalian olfactory system. Mol. Neurobiol. 39:1-9.

Briançon-Marjollet, A., Ghogha, A., Nawabi, H., Triki, I., Auziol, C., Fromont, S., Enslen, H., Chebli, K., Cloutier, J.-F., Castellani, V., Debant, A., Lamarche-Vane, N. (2008) Trio mediates netrin-1-induced Rac1 activation and axon guidance. Mol. Cell. Biol. 7: 2314-2323.

Cho, J.H., Lépine, M., Andrews W., Parnavelas, J., Cloutier, J.-F. (2007) Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb. The Journal of Neuroscience 27: 9094-9104.

Cloutier, J.-F., Sahay, A., Chang, E.C., Tessier-Lavigne, M., Dulac, C., Kolodkin, A.L., Ginty, D.D. (2004) Differential requirements for Sema3F and Slit-1 in axonal fasciculation, targeting, and segregation of olfactory receptor sensory neurons. J. Neurosci. 24: 9087-9096. [PDF]

Huber, A.B., Kolodkin, A.L., Ginty, D.D., Cloutier, J.-F. (2003) Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Ann. Rev. Neurosci. 26:509-63. [PDF]

Cloutier, J.-F., Giger, R.J., Koentges, G., Dulac, C., Kolodkin, A.L., Ginty, D.D. (2002) Neuropilin-2 mediates axonal fasciculation, zonal segregation, but not axonal convergence of primary accessory olfactory neurons. Neuron 33: 877-92. [PDF]